cyclist was killed near Holborn station in a rush-hour collision with an HGV on Tuesday morning.
The rider could not be saved by doctors and paramedics and was declared dead at the scene.
The collision happened just after 10am.
The cyclist, who has not been identified, is the first person to die cycling in London in 2022 and the sixth to die in the Holborn area in nine years.
The collision is believed to have happened at the junction of High Holborn, Procter Street and Kingsway, close to the Tube station entrance.
A London Ambulance Service spokesperson said: “We were called at 10:06 am today to reports of a road traffic collision involving a cyclist outside Holborn Underground station.
“We sent a paramedic in a fast response car and an incident response officer to the scene. We also dispatched London’s Air Ambulance. The first of our medics arrived in under five minutes.
“Sadly, a person died at the scene.”
The Met police said the incident was outside the Tube station, which would have been closed due to the Tube strike.
“A HGV was reported to be in collision with a cyclist,” it said in a statement.
“The London Ambulance Service and London Fire Brigade attended the scene. The cyclist was pronounced dead at the scene. ”
“Local road closures are in place while emergency services deal.”
The Met said no arrests had been made and inquiries were continuing.
Ten people were killed cycling in London last year.
The incident appears to have happened only yards where cyclist Alan Neve was killed by a HGV in 2013.
Traffic from Procter Street comes together with westbound traffic from High Holborn as part of the notorious Holborn gyratory in this location.
Last August Dr Marta Krawiec was fatally injured by an HGV as it turned left at the junction of Theobalds Road and Southampton Row, about 200 yards further north from the latest fatal collision.
Transformation of the Holborn gyratory has been delayed due to Transport for London having a lack of funds, primarily due to a collapse in income resulting from the pandemic.
However Camden council did implement temporary changes at the Theobalds Road / Southampton Row junction last September and began making them permanent in January.
Last year the London Cycling Campaign demanded safety changes at Holborn and other deadly junctions.